Fig. 6: Time course of immunoassay-based IgG levels in relation to neutralizing antibody response at baseline. | Nature Communications

Fig. 6: Time course of immunoassay-based IgG levels in relation to neutralizing antibody response at baseline.

From: Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany

Fig. 6

There was a strong association between the magnitude of the immunoassay-based IgG response and the probability of levels of neutralizing antibodies (NAb) decreasing below detection limit (odds ratio for time (in days) × IgG ratio interaction = 0.96, 95% CI: 0.94–0.98, two-sided P << 0.001, using generalized estimating equations with a cumulative logistic link function and an independent covariance structure, and deriving the confidence intervals from the robust Huber-White sandwich variance estimator). The four individuals, who became NAb negative during follow-up, had relatively modest IgG responses (right panel). Sample size: 22 individuals with SARS-CoV-2 neutralizing antibodies at baseline. The horizontal dotted lines represent the borders of the indeterminate range.

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