Fig. 1: B1a cell development is marked by a pronounced loss of CpG modification. | Nature Communications

Fig. 1: B1a cell development is marked by a pronounced loss of CpG modification.

From: B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

Fig. 1: B1a cell development is marked by a pronounced loss of CpG modification.

a Distribution of HMR lengths in proB and B cells in the B1a and B2 lineage. B1a, B2 and proB2 cells were pooled from three mice each, and proB1 cells were pooled from 14 fetal livers. b Number of canyons (HMR length >3.5 kb) identified in proB2, B2 (follicular B), proB1 and B1a cells (n = 1 methylome each; DNA was pooled from multiple mice as indicated in Fig. 1a). c CpG modification profiles in developmental DMRs in the B1a and B2 lineages. Average CpG modification ratio in the B1a and B2 DMRs in proB1, B1a, proB2 and B2 cells is depicted in the heatmap. d The number of DMRs identified by pairwise comparisons between proB and mature B cells and between corresponding stages of the B1a and B2 cell lineages. e Overlap between B2 and B1a DMRs; DMRs with over 50% overlap were considered overlapping. f Distribution of development DMR lengths in proB and B cells in the B1a and B2 lineage. Source data are provided as a Source Data file.

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