Fig. 7: SD limits the spatial reach of seizures across the cortex.
From: Spreading depression as an innate antiseizure mechanism
A Diagram showing the ROI placement for IOS analysis. B–D The proportion of animals that developed hyperemia within each of the five ROIs coupled to 4AP, PG, or BIC seizures show that the spatial reach of seizures was diminished by an SD induced 30 min before (−30 min), 5 min before (−5 min) or 30 min after (+30 min) drug application. All SDs were remotely induced by topical KCl application using the setup shown in Supplementary Fig. 1B, b. The control group did not receive any SD intervention from outside, but 22 animals in 4AP, 3 animals in PG, and 1 animal in the BIC control group developed spontaneous SDs (as summarized in Fig. 3A, B). Red circles indicate the average distance hyperemic transients reached from the drug application site in each subgroup (no hyperemic transients in any ROI is 0 mm). *-**p < 0.05-0.01 vs. control, one-way ANOVA followed by Dunnett’s multiple comparison’s tests (±SEM).
