Fig. 8: Spontaneously occurring SD terminates focal cortical seizures and limits their reemergence. | Nature Communications

Fig. 8: Spontaneously occurring SD terminates focal cortical seizures and limits their reemergence.

From: Spreading depression as an innate antiseizure mechanism

Fig. 8

Average ECoG power time course in δ (0–4 Hz), θ (4–8 Hz), and α (8–12 Hz) frequency bands show ECoG power at rest, during the seizure (5 min prior to SD, and every minute thereafter, expressed as % of pre-SD seizure power. Spontaneously arising SD significantly diminished seizure intensity (bold curves) compared with controls without an SD (faint curves) in δ (0–4 Hz) and θ (4–8 Hz) bands (two-way ANOVA for repeated measures; ±SEM). Sample sizes are shown on the graph. Only the first SD in each experiment is analyzed.

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