Fig. 1: Flow chart of analysis steps.
From: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
Discovery meta-analysis in GR@ACE, IGAP stage 1 + 2 and UKBiobank followed by a replication in 16 independent cohorts. The genome-wide significant signals found in meta-GWAS were used to perform a Polygenic Risk Score in a clinical and pathological AD dataset. See Supplementary Methods to more information about the cohorts included and methods to the PRS generation. aExtended dataset (Moreno-Grau et al.19), bStageI + StageII (Kunkle et al.20), cBy proxy AD: Meta-analysis of maternal and paternal history of dementia (Marioni et al.21), dExtra and independent GR@ACE dataset incorporated only for replication purposes, ePathologically confirmed AD cases, fAD cases diagnosed based on clinical criteria, gControls participants aged 55 years and younger. N = Total of individuals within specified data.
