Fig. 2: Immersive network exploration.
From: The VRNetzer platform enables interactive network analysis in Virtual Reality
a Green-screen composition showing a user immersed in the genome-scale molecular interaction network. b Network annotations at different scales: individual nodes are annotated with detailed information shown in a separate inspection panel. Meso-scale node clusters (representing, for example, biological functions or disease-associated processes) are annotated using floating labels derived from gene set enrichment and network proximity. Functional landscapes represent global network views in which neighborhoods and their respective annotations are highlighted. Our platform includes functional landscapes for gene annotations according to gene ontology (GO) and disease associations. c The dynamic transition functionality allows for exploring different roles of a particular gene or gene set across different contexts. Starting, for example, in a functional landscape showing the biological processes that a gene set is involved in (here: NADH-dehydrogenase activity; top panel), the positions of all nodes smoothly transition toward a functional landscape that highlights disease neighborhoods in which the respective genes are located.
