Fig. 2: STING controls the in vivo response to radiation.
From: STING enhances cell death through regulation of reactive oxygen species and DNA damage
a Schematic of in vivo tumor growth delay experiments and fractionated treatment protocol with ionizing radiation. b Tumor growth curves for tumors generated from WT or STING KO FaDu cells implanted subcutaneously in athymic nude mice (error bars represent SEM for n = 6 for unirradiated groups and n = 7 for irradiated groups). *P-values for 21, 23, 25, 28, 39, 32, 35, 37, 39, and 42 days are 0.04, 0.02, 0.01, 0.005, 0.003, 0.0007, 0.0003, <0.0001, <0.0001, and <0.0001 based on two-way ANOVA with Fisher’s LSD post-hoc analysis without multiple comparison correction. c Quantification of tumor growth delay from radiation treatment (time to reach 600 mm3) from b (error bars represent SEM of n = 7 WT tumors and n = 7 STING KO tumors; P-value from unpaired, two-tailed Student’s t test). d Tumor growth delay curves from WT or STING silenced Detroit562 tumors (error bars represent SEM of n = 9 tumors for STING KD + RT group and n = 8 for all others). *P-values for 7, 9, 11, 14, and 16 days are 0.049, 0.002, <0.0001, <0.0001, and <0.0001 based on two-way ANOVA with Sidak post-hoc multiple comparison correction. e Quantification of tumor growth delay from radiation treatment (time to reach 600 mm3) from d (error bars represent SEM of n = 8 WT tumors and n = 9 STING KD tumors; P-value from unpaired, two-tailed Student’s t test).
