Fig. 4: Mosquito infectivity and gametocyte density.

A Total gametocyte density in the different cohort participants in relation to the percentage of mosquitoes that became infected. Light blue hollow markers = chronic asymptomatic infection, dark blue solid markers = chronic symptomatic infection, light red hollow markers = incident asymptomatic infection, dark red solid markers = incident symptomatic infection. The black line indicates the shape of the model for the association of gametocyte density and percentage of mosquitoes infected in mosquito feeding assays for individuals with chronic infections. This model is described in detail elsewhere²⁴. Grey shading represents the 95% confidence interval for the model. This figure is based on 134 observations from chronic asymptomatic infections, 26 observations from chronic symptomatic infections, 3 observations from incident asymptomatic infections, and 49 observations from incident symptomatic infections. B The percentage of mosquitoes infected over time, shown as days since the start of intensive follow-up. Colours (markers and lines) are as in (A). The size of the data points is proportional to the log gametocyte density in blood samples taken concurrent with the mosquito feeding assay. Connecting lines indicate observations from the same cohort participant.