Fig. 4: Morphometric analysis of viral antigen and drug concentration in the lungs.
From: Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
a A longitudinal cross section of the right lung of each animal (N = 6 per group) was stained for viral antigen and scanned to measure the total amount of viral antigen present in the lung section. b EIDD-1931 concentrations in the lungs. a, b Blue circle, vehicle control; red square, pre-infection treatment; green triangle, post-infection treatment. Summary of results. a The area of lung staining positive for viral antigen showed a statistically significant difference between both of the MK-4482 treatment groups, compared to vehicle controls. No difference between individual treatment groups was present. (One-way ANOVA followed by Kruskal–Wallis analysis and a pairwise Wilcox test was used to analyze differences among groups. **p < 0.008).
