Fig. 8: TCR α chain sequencing of peptide-stimulated PBMCs from Pandemrix-associated NT1 patients. | Nature Communications

Fig. 8: TCR α chain sequencing of peptide-stimulated PBMCs from Pandemrix-associated NT1 patients.

From: Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

Fig. 8: TCR α chain sequencing of peptide-stimulated PBMCs from Pandemrix-associated NT1 patients.

TCR α chains (TRA) were sequenced from the same RNA samples as used for RNA sequencing. P: patient; HC: healthy control. Displayed are TRA clonotypes that were upregulated in ≥3 NT1 patient samples, based on fold changes between peptide- (NA175–189- or POMT1675–689-) treated and medium control samples from the same participant in data normalized by downsampling (heatmap). Statistical significance on the group level (NT1 patients only; Rank products test; proportion of false positives <0.05) is indicated on the left side bar.

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