Fig. 3: Frequencies of AMR genetic determinants within individual S. sonnei genotypes, calculated across 6715 genomes. | Nature Communications

Fig. 3: Frequencies of AMR genetic determinants within individual S. sonnei genotypes, calculated across 6715 genomes.

From: Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei

Fig. 3

Cells indicate absence (white) or presence (coloured by proportion as per legend) of each AMR determinant (columns) within each clade or higher-resolution genotype (rows). All clades are included as rows (bold labels); subclades and higher-resolution genotypes represented by ≥10 genomes are also included as distinct rows; number of genomes in each row are noted in column “N”. Light blue shading indicates fluoroquinolone resistant genotypes; dark blue shading indicates MSM-associated genotypes. Columns are grouped by typical location of the AMR determinant (labelled horizontal bars at the top): transposon Tn7, represented by marker genes tnsABCDE and class II integron In2 integrase gene intA2; Shigella resistance locus (SRL); spA plasmid, represented by marker gene rep; other mobile elements; mutations in quinolone resistance determining region (QRDR). Column “other Agly” indicates proportion of genomes carrying at ≥1 additional aminoglycoside resistance gene beyond those with their own columns; column ‘other’ indicates proportion of genomes carrying ≥1 other AMR gene that is not otherwise listed (full AMR gene content per strain is available in Supplementary Data  1).

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