Fig. 6: Differential alterations in expression of excitatory and inhibitory postsynaptic density proteins are associated with dementia in AD. | Nature Communications

Fig. 6: Differential alterations in expression of excitatory and inhibitory postsynaptic density proteins are associated with dementia in AD.

From: Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

Fig. 6

a The transcriptional E/I ratio for DLG4 to GPHN (DLG4/GPHN) using RNA-Seq datasets from the Aging, Dementia and Traumatic Brain Injury study (ADTBI), was significantly increased in AD cases compared to controls with no pathology (n = 8 cognitive healthy controls, CERAD = 0 and 12 subjects with a DSM-IV clinical diagnosis of dementia of the AD disease type and AD pathology CERAD = 3). The difference was driven by reduction in GPHN expression and not from DLG4, P value from the non-parametric two-sided Wilcoxon test. b Top representative clusters of the gene ontology (GO) analysis for cellular component of genes positively correlated with the DLG4/GPHN ratio implemented in Metascape. c Top representative clusters of the gene ontology analysis for co-expression modules differentially expressed between AD and control cases. See Supplementary Data 5–9 for details in gene correlations, GO enrichment, differential expression, and module membership.

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