Table 2 Inverse-variance weighted fixed effects meta-analysis of EWAS with coffee consumption.
From: Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
CpG | CHR | Position | Gene | Discovery phase (n = 9612) | Replication phase (n = 6177) | Overall meta-analysis n = 15,789) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | I2 | Direction | Het P-v | ||||
cg05575921 | 5 | 373378 | AHRR | −0.0014 (2E−04) | 2.33E−10 | −0.0027 (5E−04) | 7.93E−08 | −0.0016 (2E−4) | 2.17E−15 | 70.3 | ----+---+-------+ | 0 |
cg25648203 | 5 | 395444 | AHRR | −0.001 (2E−04) | 1.87E−09 | −0.0011 (2E−04) | 8.02E−06 | −0.001 (1E−4) | 7.31E−14 | 21.7 | ----+---+-------- | 0.2 |
cg03636183 | 19 | 17000585 | F2RL3 | −0.0014 (2E−04) | 1.04E−10 | −0.0014 (5E-04) | 2.95E−03 | −0.0014 (2E-4) | 1.15E−12 | 37.9 | ---++---------+-+ | 0.06 |
cg21161138 | 5 | 399360 | AHRR | −0.0011 (2E−04) | 1.81E−09 | −0.001 (3E−04) | 9.01E−04 | −0.0011 (2E−4) | 6.66E−12 | 0 | ----------------- | 0.47 |
cg15928106 | 7 | 130646078 | FLJ43663 | 0.0014 (2E−04) | 1.14E−06 | 0.0022 (7E−04) | 1.60E−03 | 0.0015 (3E−4) | 1.59E−08 | 52.3 | +--+-++++-+++++-- | 0 |
cg11550064 | 2 | 240148191 | HDAC4 | 0.0007 (2E−04) | 1.41E−06 | 0.0006 (6E−04) | 4.06E−03 | 0.0007 (1E−4) | 2.11E−08 | 47.2 | --+++++-++++++-+- | 0.01 |
cg09935388 | 1 | 92947588 | GFI1 | −0.0012 (2E−04) | 7.78E−07 | −0.0013 (5E−04) | 8.89E−03 | −0.0012 (2E−4) | 2.32E−08 | 36.9 | ----+---+------++ | 0.06 |
cg20228731 | 7 | 130646051 | FLJ43663 | 0.0014 (3E−04) | 1.14E−06 | 0.0017 (7E−04) | 9.69E−03 | 0.0015 (3E−4) | 3.87E−08 | 48.4 | ++---++++-++++++- | 0.01 |
cg06126421 | 6 | 30720080 | NA | −0.0009 (2E−04) | 1.15E−04 | −0.0021 (5E-04) | 7.91E−06 | −0.0011 (2E−4) | 4.50E−08 | 43.8 | ----+--++------?- | 0.03 |
cg14476101 | 1 | 120255992 | PHGDH | 0.0011 (2E−04) | 4.41E−06 | 0.0015 (5E−04) | 2.21E−03 | 0.0011 (2E−4) | 4.71E−08 | 0.0 | -++++++++++++++++ | 0.99 |
cg23916896 | 5 | 368804 | AHRR | −0.0011 (2E−04) | 4.34E−05 | −0.0019 (5E−04) | 8.55E−05 | −0.0013 (2E−4) | 4.76E−08 | 0.0 | ---+----+----+--+ | 0.86 |
