Table 3 Inverse-variance weighted fixed effects meta-analysis of EWAS with tea consumption.

From: Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

CpG

CHR

Position

Gene

Overall meta-analysis (n = 15,069)

Β (SE)

P-value

I2

Direction

Het P-v

cg20099906

19

13344820

CACNA1A

−0.0008 (2E−04)

1.06E−06

17.7

-+-+--++--+--+--

0.25

cg05804170

1

3121514

PRDM16

−0.0002 (2E−04)

2.11E−06

0

-+--+-+-+----++-

0.98

  1. The model is adjusted for sex, age, smoking, WBCs, technical covariates, BMI, and alcohol consumption. The epigenome-wide significance threshold for association of DNA methylation sites with tea consumption sets at 1.1 × 10−7. The table depicts two CpGs suggestively associated with tea consumption with a borderline p-value between 2.0 × 10−6 and 1.1 × 10−7.
  2. CpG DNA methylation site, CHR chromosome, Gene annotated gene, β effect estimate, I2 heterogeneity.
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