Fig. 6: In vivo propensity for catecholamine-induced bidirectional VT displays diurnal rhythmicity.
From: Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia
A Typical ECG traces before (baseline) and after injection of caffeine and adrenaline. Animals displayed rapid tachycardia, typically followed by bradycardia and sinus pauses and/or premature complexes, with some progressing into bidirectional VT (bottom right). Vertical scale bars represent 0.5 mV and inset times are time from returning to the cage after injection. B Proportion of animals that display evidence of each stage of VT progression. At ZT12, all control animals (six of six mice tested) displayed robust evidence of bidirectional VT, compared to only one of six mice tested at ZT0. Only two of five αMHCCREBmal1Fl/Fl mice displayed bidirectional VT at ZT12. *P < 0.05, **P < 0.01, Chi-square. Source data and statistical details are provided as a Source Data File.
