Fig. 8: Cell type-specific regulons.
From: Single nucleus multi-omics regulatory landscape of the murine pituitary
a Schematic of a cell type-specific regulon, using FOXP2 as an example. A regulon consists of a TF driver (e.g., FOXP2) and its target genes. The regulon genes are cell type-specific (e.g., they differ in stem cells vs. gonadotropes). b Dot plot of the top regulons in male gonadotropes and their relative expression in other cell types. The color scale is indicated. The dot size symbolizes the percentage of cells expressing that regulon. c UMAP and cell type identification from the SCENIC regulon analysis recapitulates the clusters identified by data integration (Fig.5c). d Venn diagram of the overlap of FOXP2 regulon genes between the different cell types in males. e Scatter plots showing the correlation between relative promoter accessibility and relative gene expression for the 1,676 genes composing the FOXP2 regulon in male gonadotropes (Left) and male melanotropes (Right). Characteristic gonadotrope and melanotrope genes are framed in red. f Annotated gene modules showing the different functions associated with the FOXP2 regulon in gonadotropes (Left) and in melanotropes (Right). Refer to Supplementary Fig. 24 for the corresponding analysis of female samples.
