Fig. 9: Model of cell type-specific regulon control mechanisms.
From: Single nucleus multi-omics regulatory landscape of the murine pituitary
Schematic of the proposed mechanisms for cell type-specific regulation of regulon composition and function. Three layers of control shape the expression and composition of a cell type-specific regulon and its biological function: cell type-specific expression of the TF driver, presence of cis-regulatory domain at the target gene promoter, and epigenetic control of promoter accessibility.
