Fig. 3: Precision of the predicted inter-residue contacts. | Nature Communications

Fig. 3: Precision of the predicted inter-residue contacts.

From: CopulaNet: Learning residue co-evolution directly from multiple sequence alignment for protein structure prediction

Fig. 3

Here, the most probable L/5, L/2 and L long-range residue contacts are shown, where L represents protein length. The phrase "long-range" refers to two residues with sequence separation over 24 residues. For all CASP13 target proteins, ProFOLD outperformed the state-of-the-art approaches. In particular, for the 31 FM domains, ProFOLD achieved precision of 0.840, 0.713 and 0.567 for the most probable L/5, L/2 and L contacts, which is significantly higher than AlphaFold, by 0.128, 0.117 and 0.097, respectively.

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