Fig. 2: Effect of peripheral Y1R antagonism on food intake and energy expenditure in wild-type mice. | Nature Communications

Fig. 2: Effect of peripheral Y1R antagonism on food intake and energy expenditure in wild-type mice.

From: Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

Fig. 2: Effect of peripheral Y1R antagonism on food intake and energy expenditure in wild-type mice.

a Spontaneous daily food intake over first 3 days of wild-type mice treated daily with a jelly containing either vehicle or BIBO3304 on a chow or a HFD at 8 weeks of age, Data are mean ± s.e.m, Chow n = 5 (control: open grey bar; BIBO3304: grey bar), HFD n = 8 (control: open blue bar; BIBO3304: blue bar). p values by one-way ANOVA. b Cumulative food intake of chow- and HFD-fed wild-type mice treated daily with a jelly containing either vehicle or BIBO3304 from day 6 to day 20 post treatment. Data are mean ± s.e.m, Chow n = 5 (grey, control: open square; BIBO3304: filled square), HFD n = 8 (blue, control: open circle; BIBO3304: filled circle). p values by two-way repeated measures ANOVA. c Food intake during the dark phase, light phase and over 24 h period of chow- and HFD-fed wild-type mice treated daily with a jelly containing either vehicle or BIBO3304 at 8–9 weeks of age. Data are mean ± s.e.m, n = 6 per group. p values by one-way ANOVA. d Energy expenditure (normalized to metabolically active tissues) over a 24-h course, with e showing average energy expenditure during the light phase, dark phase and over a 24-h period from (d). f Respiratory exchange ratio (RER) over a 24-h period, with (g) showing RER during the light phase, dark phase and over a 24-h period from (f). Data (d, e, f, g) are mean ± s.e.m. Chow n = 6, HFD n = 10, *p < 0.05, **p < 0.01 vs control in the same diet, one-way ANOVA with Tukey’s multiple comparisons test. Source data are provided as a Source Data file.

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