Fig. 6: Proposed model for floor plate induction and patterning in hNTOs.
From: Actuation enhances patterning in human neural tube organoids
Induction of the FP requires active contractility and PCP. FP patterning enhancement relies on hNTO actuation in a matrix stiffness-dependent manner. Soft and stiff matrices result in no FP patterning enhancement upon actuation. In intermediate stiffness, actuated hNTOs exhibit higher FP patterning events linked to increased cytoskeleton and ECM remodeling activity.
