Fig. 6: NAbs and antibody (IgG) to S2 HCOV-OC43 and HKU1 and SARS-CoV-2.

Sera of COVID-19 patients, collected at the indicated timepoint from symptoms onset, were measured by LV-based-neutralization assay and the LIPS to SARS-CoV-2 and HCoV S2 spike antigen as indicated. a Boxes under the diagonal show each correlation plot of the reciprocal of the ID50 and arbitrary units after log1p transformation. Dots correspond to individual measurements, the black line represents the regression line and the gray area its 95%CI. Boxes on the diagonal show as histograms the distribution of values in each assay. Boxes above the diagonal show the corresponding Pearson correlation analysis coefficients. Asterisks correspond to the following p values: ***p ≤ 0.001; **p ≤ 0.01; *p ≤ 0.05. b Shown are box plot displaying median of each antibody response as indicated, IQR, and whiskers extending to 1.96 times the IQR, stratified by sampling at the indicated week from symptoms onset and a negative or positive nAb response. c Development and kinetics of nAb responses to SARS-CoV-2 during follow-up of patients with negative or positive nAb score at the in-hospital sampling. Each colored dot corresponds to the reciprocal of the ID50 of a serum of a given infected individual stratified for low, medium or high IgG to HCoV S2 antigens. Shown is the moving average of data + SE (black curve line + gray band) as obtained by a LOESS curve fitting polynomial regression. Source data are provided as a Source Data file.