Fig. 5: Exploration of structure-function associations in the dHCP dataset.

The structural feature per white matter tract is the voxelwise mean diffusion parameter: mean diffusivity, fractional anisotropy, and mean kurtosis. The functional feature is the predicted noxious-evoked response amplitude, generated using the resting-state prediction model. a The three plots display the Pearson correlation coefficients (x-axis) between response amplitudes and diffusion parameters for all 16 white matter tracts (y-axis). The white matter tracts are ordered according to the mean diffusivity correlation coefficients for which statistically significant results were found (red). Statistical significance is FWER-corrected for multiple testing across all 48 Pearson correlation tests. b Maps displaying the five bilateral white matter tracts statistically significantly related to predicted noxious-evoked response amplitudes. ar acoustic radiation, atr anterior thalamic radiation, cgc cingulate gyrus part of the cingulum, cgh parahippocampal part of the cingulum, cst corticospinal tract, fma forceps major, fmi forceps minor, for fornix, ifo inferior fronto-occipital fasciculus, ilf inferior longitudinal fasciculus, mcp middle cerebellar peduncle, ml medial lemniscus, ptr posterior thalamic radiation, slf superior longitudinal fasciculus, str superior thalamic radiation, unc uncinate fasciculus. Source data are provided as a Source Data file.