Table 1 Optimization of reaction conditionsa.

From: Diversity-oriented functionalization of 2-pyridones and uracils

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Entry

[NBE]

x

Yield [%]b

1

N1

1.0

27

2

N2

1.0

40

3

N3

1.0

28

4

N4

1.0

27

5

N5

1.0

20

6

N6

1.0

30

7

N7

1.0

60

8

N8

1.0

80

9

N8

0.5

78

10c

N8

0.5

83

11d

N8

0.5

92

12d,e

N8

0.5

98 (95)f

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  1. aAll reactions were performed on a 0.1-mmol scale, the ratio of 1a: 2a: 3a = 1:1.5:1.5.
  2. b1H-NMR yield with 1,3,5-trimethoxy-benzene as an internal standard.
  3. cThe ratio of 1a: 2a: 3a = 1.0:1.5:1.0.
  4. dThe ratio of 1a: 2a: 3a = 1.2:1.5:1.0.
  5. eThe reaction time was increased to 36 h.
  6. fIsolated yield in parentheses, which is calculated based on 3a.
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