Table 2 Reaction scope of 2-pyridone and alkylating reagent.

From: Diversity-oriented functionalization of 2-pyridones and uracils

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  1. aAll reactions were performed on a 0.1-mmol scale. Reported yields are for the isolated products.
  2. bOn a 3.0-mmol scale.
  3. cR = H. The reaction was performed with 2.5 equiv of 2a and 3.5 equiv of K2CO3.
  4. dThe reaction was performed with 3.0 equiv of 2a, 5.0 equiv of K2CO3, and 1.0 equiv of N8.
  5. eThe reaction was performed with 10 mol% Pd(OAc)2, 1.0 equiv of N8 and heated at 130 °C for 48 h.
  6. f1H-NMR yield with 1,3,5-trimethoxy-benzene as an internal standard.
  7. gCD3OTs was utilized as the alkylating reagent.
  8. hBenzyl chloride was utilized as the alkylating reagent.
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