Fig. 5: APRIL-deficient mice are protected from obesity development.

a–j WT and APRIL^−/− mice were fed HFD for 20 weeks. a Systemic BAFF concentration quantified by ELISA. b Weight gain. c Tissue weight distribution as indicated at time of harvest. d Food Intake. e Combined energy expenditure at 16 weeks of HFD analyzed by TSE Phenomaster system. f Fasting glucose at 20 weeks of HFD. g GTT at 14 weeks of HFD. h AUC. i Fasting insulin at 20 weeks of HFD. j Systemic ALT at 20 weeks of HFD. k Weight gain of WT, BAFF^−/−, APRIL^−/−, or BAFF^−/−/APRIL^−/− mice fed HFD for 20 weeks. a–j Representative of three independent experiments, n = 6-7/condition. a–j For bar and line graphs, data represent mean ± SEM. a, c–f, i–j Unpaired two-tailed Student’s t test. *p < 0.05, **p < 0.01, ***p < 0.001. b, g–h Area under the curve. **p < 0.01, ****p < 0.0001. Source data are provided as a Source data file.