Fig. 6: Lack of BAFF and APRIL exacerbates diet-induced weight gain.

a Weight gain of WT, BAFF^−/−, APRIL^−/−, and BAFF^−/−/APRIL^−/− mice fed HFD for 20 weeks. b–f WT and BAFF^−/−/APRIL^−/− mice fed HFD for 20 weeks. b Tissue weight distribution as indicated at time of harvest. c Fasting glucose at 14 weeks of HFD. d GTT at 14 weeks of HFD. e AUC. f Systemic ALT at time of harvest. a A single experiment, n = 3–6/condition. b–f A single experiment, n = 3–4/condition. a–f For bar and line graphs, data represent mean±SEM. a, d Area under the curve. b–c, e–f Unpaired two-tailed Student’s t test. a–e *p < 0.05, ****p < 0.0001. Source data are provided as a Source data file.