Table 2 Univariate and multivariable analysis on patient cohort in TMA analysis.

From: Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer

 

Univariate analysis

Logistic regression—CR

Cox regression—OS

OR (95% CI)

p-value

HR (95% CI)

p-value

Age (year)

1.01 (0.96–1.06)

0.71

1.03 (1.00–1.06)

0.05

Gender (Male vs. female)

0.48 (0.17–1.37)

0.17

1.05 (0.57–1.95)

0.88

BMI pre-treatment

1.05 (0.96–1.15)

0.27

0.94 (0.89–0.99)

0.03

ECOG (0/1 vs. 2/3)

1.64 (0.33–8.23)

0.55

3.3 (1.90–5.73)

<0.001

Smoking (Never vs. past/current)

0.33 (0.10–1.08)

0.07

1.47 (0.82–2.64)

0.2

Diabetes (No vs. Yes)

0.67 (0.24–1.87)

0.44

1.04 (0.59–1.84)

0.89

LVI (No vs. Yes)

0.51 (0.19–1.41)

0.20

1.81 (1.05–3.12)

0.03

Tumor Stage (T2 vs. T3)

0.66 (0.15–2.88)

0.58

3.36 (1.74–6.47)

<0.001

PMN/CD8 tumor (Low vs. High)

0.21 (0.05–0.75)

0.02

1.89 (1.00–3.53)

0.04

NETs post-RT (No vs. Yes)

NA

 

2.64 (1.23–5.62)

0.01

 

Multivariable analysis

 

Logistic regression—CR

Cox regression—OS

 

OR (95% CI)

p-value

HR (95% CI)

p-value

LVI (No vs. Yes)

  

2.22 (1.15–4.28)

0.02

PMN/CD8 in tumor (Low vs. High)

0.18 (0.04–0.72)

0.02

  

NETs post-RT (No vs. Yes)

NA

 

3.75 (1.67–8.44)

<0.001

  1. Multivariable logistic regression was performed to assess the role of each covariates on a complete response post-RT. In order to estimate the impact of each variable on overall survival a Cox model was performed. Log linearity hypothesis were verified for quantitative variables and proportional hazard assumptions were verified for all variables. Final multivariate model was created using a stepwise selection method. Statistical significance was set at 5%.
  2. CR complete response, OS overall survival, OR odds ratio, HR hazard ratio, BMI body-mass index, NA Non applicable.
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