Fig. 2: Refinement of Rosetta-SWM models and base-pair-restrained prediction of RNA structural motif by BRiQ. | Nature Communications

Fig. 2: Refinement of Rosetta-SWM models and base-pair-restrained prediction of RNA structural motif by BRiQ.

From: Pairing a high-resolution statistical potential with a nucleobase-centric sampling algorithm for improving RNA model refinement

Fig. 2

A Refining Rosetta-SWM motif models by BRiQ improves the majority of those model structures with RMSD<2 Å as demonstrated by RMSD comparison (lowest RMSD of top 1% before refinement on Y-axis versus after refinement on X-axis). B Fixing all native base pairs with random initial conformations for all other regions and then folding the remaining structure leads to more accurate motif models for the majority of the motifs than refining Rosetta-SWM models that have pre-assigned, partially fixed base pairs (Lowest RMSD of top 1% BRiQ-refined models on Y-axis versus lowest RMSD of top 1% BRiQ models with fixed native base pairs on X-axis).

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