Fig. 2: Crystal structure of the hTOM70/SARS-CoV-2 orf9b complex. | Nature Communications

Fig. 2: Crystal structure of the hTOM70/SARS-CoV-2 orf9b complex.

From: Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

Fig. 2

a Left, ribbon model of the hTOM70 cytosolic domain with SARS-CoV-2 orf9b occupying the CTD pocket. The NTD of hTOM70 is colored blue, the CTD is cyan and orf9b is magenta. Tetratricopeptide repeat (TPR) motifs and secondary structure elements are indicated. Right, magnified view of SARS-CoV-2 orf9b inside the CTD pocket. The omit map (black mesh, calculated by program phenix.composite_omit_map) for orf9b is superimposed on the model. b Ribbon models of dimeric SARS-CoV-2 orf9b and the central portion of the same protein when bound to hTOM70. The segment of SARS-CoV-2 orf9b 43-78 adopts a β-strand rich structure in its dimeric form (right) and an α-helix rich structure in its bound form (left). c–e Details of polar interactions between SARS-CoV-2 orf9b and hTOM70.

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