Fig. 1: Structure and binding site of hBLT1.
From: Structural insights on ligand recognition at the human leukotriene B4 receptor 1
a Structure of hBLT1 (wheat cartoon) in complex with MK-D-046 (spheres with cyan carbons). Small spheres (wheat) indicate membrane boundaries (EC, extracellular side; IC, intracellular side), as obtained from the Orientations of Proteins in Membranes (OPM) database66. Sodium (Na+, purple) and water (red) are shown as spheres. b Extracellular view of hBLT1 showing the solvent-exposed orthosteric binding pocket. c Chemical structure of MK-D-046 showing ligand-interacting residues within 4 Å. Critical residues evaluated in our functional and/or binding studies are colored red (polar interactions) or blue (hydrophobic interactions). Hydrogen bonds are shown as dashed red lines. d Refined 2mFo-DFc electron density (gray mesh), contoured at 1.0 σ, around MK-D-046 and ligand-interacting residues within 4 Å from MK-D-046.
