Fig. 2: NI301A binds TTR amyloid present in sporadic and hereditary cases of ATTR amyloidosis with cardiomyopathy and polyneuropathy. | Nature Communications

Fig. 2: NI301A binds TTR amyloid present in sporadic and hereditary cases of ATTR amyloidosis with cardiomyopathy and polyneuropathy.

From: A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells

Fig. 2: NI301A binds TTR amyloid present in sporadic and hereditary cases of ATTR amyloidosis with cardiomyopathy and polyneuropathy.

a IHC using NI301A on frozen post-mortem heart tissues collected from three sporadic cases with ATTRwt cardiomyopathy, a case without amyloid (A−), and one with non-TTR amyloid deposits (A+TTR−). ATTR deposits were identified by Congo red staining with birefringence and immunostaining with the pan-TTR antibody Dako A0002. b IHC using NI301A and Congo red staining on frozen salivary gland biopsies collected from ATTRv cardiomyopathy patients carrying the variants TTR-T49I, T60A, I68L, S77T, and V122I. c IHC using NI301A and Dako A0002 on skin biopsy from a patient with ATTR-V30M polyneuropathy and on human pancreas tissue. d IHC using NI301A and Dako A0002 on abdominal fat aspirates from two patients with ATTR-V30M polyneuropathy.

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