Fig. 1: Experimental design of 3 T fMRI imaging with DBS activation in PD patients. | Nature Communications

Fig. 1: Experimental design of 3 T fMRI imaging with DBS activation in PD patients.

From: Predicting optimal deep brain stimulation parameters for Parkinson’s disease using functional MRI and machine learning

Fig. 1: Experimental design of 3 T fMRI imaging with DBS activation in PD patients.The alternative text for this image may have been generated using AI.

A DBS patient implanted with bilateral fully internalized and active DBS electrodes targeting the STN. The DBS lead (Medtronic 3387) has four contacts (width = 1·5 mm) spaced 1.5 mm apart. Using the handheld DBS programmer, DBS programming involves titrating the current delivered by adjusting multiple parameters (i.e., electrode contact, voltage, frequency, and pulse-width) in order to provide the best symptom relief. B Coronal T1-weighted image demonstrating a PD patient with fully internalized and active DBS electrodes (blue) implanted in the STN. C fMRI block design paradigm used during 3 T fMRI data acquisition. While the patient laid still in the scanner, unilateral (left) DBS stimulation was cycled ON and OFF every 30 s for six cycles. The DBS ON/OFF cycling was manually synchronized to fMRI acquisition. Each fMRI sequence was acquired at either optimal (green) or non-optimal (red) contacts or voltages. In this example, the four contacts were screened with fMRI; the a priori clinically optimal contact (marked in green) and non-optimal contacts (marked in red) are shown. DBS deep brain stimulation, fMRI functional magnetic resonance imaging, PD Parkinson’s disease.

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