Fig. 4: Association of CXCR5+CD8+T with TCGA/ACRG classification. | Nature Communications

Fig. 4: Association of CXCR5+CD8+T with TCGA/ACRG classification.

From: Intratumoral CXCR5+CD8+T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer

Fig. 4

a CD8+T%CIBERSORT-LM22 and CXCR5+CD8+T signature score in the MSI, EBV, GS, and CIN subgroups of the TCGA cohort (the TCGA classification, n = 318 patients with gastric cancer). Graph shows mean ± SD of n = 62 (MSI), n = 27 (EBV), n = 46 (GS), and n = 183 (CIN) individual patients, using statistical analysis by two-tailed unpaired t test. b CD8+T%CIBERSORT-LM22 and CXCR5+CD8+T signature score in the MSI, MSS/EMT, MSS/TP53+, and MSS/TP53− subgroups of the ACRG cohort (the ACRG classification, n = 261 patients with gastric cancer). Graph shows mean ± SD of n = 61 (MSI), n = 43 (MSS/EMT), n = 68 (MSS/TP53+), and n = 89 (MSS/TP53−) individual patients, using statistical analysis by two-tailed unpaired t test. Source data are provided as a Source data file. TCGA The Cancer Genome Atlas, ACRG Asian Cancer Research Group, MSI micro-satellite unstable, EBV Epstein–Barr virus, GS genomically stable, CIN chromosomal instability, MSS micro-satellite stable, EMT mesenchymal-like type, TP53 tumor protein 53.

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