Fig. 2: Reaction optimization. | Nature Communications

Fig. 2: Reaction optimization.

From: Construction 7-membered ring via Ni–Al bimetal-enabled C–H cyclization for synthesis of tricyclic imidazoles

Fig. 2: Reaction optimization.The alternative text for this image may have been generated using AI.

Reaction conditions: 1a (0.20 mmol), toluene (1.0 mL), under N2 for 3 h. Yield was determined by 1H NMR analysis with CH2Br2 as the internal standard. IPr = 1,3-bis(2,6-diisopropylphenyl)-2,3-dihydro-1H-imidazole. Cy3P = triisopropylphosphine. dppe = 1,2-bis(diphenylphosphino)ethane. BINAP = 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene. IMes = 1,3-dimesityl-2,3-dihydro-1H-imidazole. SIPr = 1,3-bis(2,6- diisopropylphenyl)imidazolidine. DME = 1,2-dimethoxyethane.

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