Fig. 1: Deletion of Meis genes in the limb-forming region.
From: Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
a Tamoxifen injection and experimental timeline. b Whole-mount X-gal staining in E9.5 HoxB6CreER; R26RlacZ embryos (N = 6 embryos). Scale bar = 100 μm. c, d Meis immunofluorescence at E10.5 in wild-type and M1KO;M2KO forelimbs (FL) and hindlimbs (HL) (N = 4 limbs). Scale bar = 100 μm. e M1KO;M2KO limb phenotype (N = 9 embryos). Scale bar = 500μm. Arrowheads in b and d indicate the limits of Cre recombination. In e, the dashed line delineates the FL soft tissues and the arrowhead indicates the HL region. Source images are available at Mendeley Data80 [https://data.mendeley.com/datasets/r774bxyf8d/2].
