Fig. 1: Overview of the study design and data generated.
a One human and eight nonhuman primate lymphoblastoid cell lines (LCLs) were cultured to perform a variety of high-throughput techniques, including whole genome sequencing (WGS), whole genome bisulfite sequencing (WGBS), chromatin-accessibility sequencing (ATAC-seq), chromatin immunoprecipitation sequencing (ChIP-seq) targeting five different histone modifications (H3K27me3, H3K4me1, H3K27ac, H3K4me3, and H3K36me3) and transcriptome sequencing (RNA-seq). We integrated previously published datasets from an extensively profiled human LCL (GM12878) to balance the number of human samples. b Number of sequencing reads generated per sample and experiment. Striped lines indicate data retrieved from previously published experiments79,108.
