Fig. 3: Different regulatory activities have different patterns of epigenetic and sequence conservation. | Nature Communications

Fig. 3: Different regulatory activities have different patterns of epigenetic and sequence conservation.

From: Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

Fig. 3: Different regulatory activities have different patterns of epigenetic and sequence conservation.

a Bar plots show the average number of orthologous regulatory regions across species with the corresponding color-coded epigenetic state conserved in 1, 2, 3, 4, or 5 species. Points indicate average values and the error bars represent the s.d. (n = 5 species). b Distribution of the sequence conservation scores (calculated as Z-scores of the distribution of phastCons30way29 values for non-coding regions in the same TAD85; Methods) of human orthologous regulatory regions with different epigenetic states conserved in 1, 2, 3, 4, or 5 of our primate species. Box plots show medians and the first and third quartiles (the 25th and 75th percentiles), respectively. The upper and lower whiskers extend the largest and smallest value no further than 1.5 × IQR.

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