Fig. 6: Human-specific intragenic enhancers with weak activities (hswEgE) co-localize with signals of recent human selection and acceleration and human-specific nucleotide changes. | Nature Communications

Fig. 6: Human-specific intragenic enhancers with weak activities (hswEgE) co-localize with signals of recent human selection and acceleration and human-specific nucleotide changes.

From: Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures

Fig. 6: Human-specific intragenic enhancers with weak activities (hswEgE) co-localize with signals of recent human selection and acceleration and human-specific nucleotide changes.

a Diagram with the results of the nested enrichment analysis. hswEgE-containing genes are enriched in genes targeted by putative signals of positive selection and acceleration. Epigenetic states for each species and consensus regulatory components are depicted as boxes with the same color code as Figs. 2b and 4a, respectively. b Top: Schematic representation of a hswEgE with an hSNC (nucleotide change in humans shown in red) in a gene with signals of selection and acceleration. Bottom: Venn diagram illustrating the overlap between the 56 genes containing hswEgE and with signals of selection or acceleration and the 30 genes with hswEgE and hSNCs.

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