Fig. 2: Organization of MAYV E1 and E2 ectodomains.

A Overall organization of MAYV subdomains from E1 and E2 heterodimers. B Upper view and side view of E1 (purple) and E2 (blue) ectodomains from an ASU. The quasi-3-fold axis is indicated at the center of the trimeric spike. Numbers indicate the corresponding zoomed images in (C). C Zoomed in images of MAYV ectodomains highlighting structural sidechain contacts involved in E1–E2 function and organization. MAYV density map is in mesh representation.