Fig. 9: H@CaPP combined with chemotherapy achieved the anti-metastasis therapeutic effect in orthotropic primary tumor-bearing mice.
From: Systemic metastasis-targeted nanotherapeutic reinforces tumor surgical resection and chemotherapy
a Typical lung tissues with visualized metastatic nodules (white arrows) from each group, and representative fields of lung tissues with metastasis areas (blue dotted lines) from each group with H&E. Black scale bar, 5 mm; Scale bar, 0.5 mm. b The number of metastatic nodules from the mice after intravenously administration with saline, PTX, PTX + LMWH, PTX + PIC, PTX + CaPP, PTX + D@CaPP or PTX + H@CaPP (i.v. of PTX at 5.9×10−3 mmol/kg, at a dose of piceatannol or PP at 0.020 mmol/kg, at a dose of Dextran or LMWH at 10 mg/kg) for seven times in 14 days (ANOVA, mean ± SD, n = 5 mice per group). c Survival curve of orthotropic breast tumor-bearing mice after intravenously administration with saline, PTX, PTX + LMWH, PTX + piceatannol, PTX + CaPP, PTX + D@CaPP, or PTX + H@CaPP for seven times during 14 days (n = 6 mice per group). One-way ANOVA with Tukey’s multiple comparisons test (one-sided) was used for b. Error bars represent SD.
