Table 3 Neonatal and early infantile outcomes, from birth to 2 months of life.
From: Association between confirmed congenital Zika infection at birth and outcomes up to 3 years of life
Neonatal and early infantile outcomes—from birth to 2 months of life | Confirmed congenital infection at birth | Negative testing at birth | p |
|---|---|---|---|
N = 18 | N = 111 | ||
Status at 2 months of life—no (%) | |||
Alive | 17 (94.4%) | 111 (100.0%) | 0.1400 |
Neonatal demise | 1 (5.6%) | 0 (0.0%) | 0.1400 |
Microcephaly < −3SD | |||
At birth*—no (%) | 2 (11.1%) | 1 (0.9%) | 0.0077 |
At 2 months**—no (%)a | 2/17 (11.8%) | 1 (0.9%) | 0.0077 |
Weight < −2SD | |||
At birth—no (%)* | 2 (11.1%) | 12 (10.8%) | 0.9256 |
At 2 months**—no (%)a | 2/17 (11.8%) | 8/111 (7.2%) | 0.5656 |
Structural brain anomalies—no (%) | 6 (33.3%) | 3 (2.7%) | <0.0001 |
Cortical development anomaly | 4 (22.2%) | 0 (0.0%) | <0.0001 |
Corpus callosum anomaly | 4 (22.2%) | 2 (1.8%) | 0.0030 |
Calcifications or cystic lesions | 5 (27.8%) | 1 (0.9%) | <0.0001 |
Posterior fossa anomaly | 4 (22.2%) | 0 (0.0%) | <0.0001 |
Ventriculomegaly | 4 (22.2%) | 1 (0.9%) | 0.0010 |
Ocular anomalies—no (%) | |||
Microphtalmy | 1 (5.6%) | 0 (0.0%) | 0.1400 |
Fundoscopy anomalies | 3/10 (30.0%) | 2/34 (5.9%) | 0.0330 |
Subretinal hemorrhage | 2/10 (20.0%) | 1/34 (2.9%) | 0.0599 |
Chorioretinal lacunae | 2/10 (20.0%) | 1/34 (2.9%) | 0.0599 |
Macula atrophy | 1/10 (10.0%) | 1/34 (2.9%) | 0.3462 |
Abnormal otoacoustic emission—no (%) | 2/12 (16.7%) | 1/43 (2.3%) | 0.1170 |
Severe neurologic symptoms—no (%) | 5 (27.8) | 1 (0.9%) | <0.0001 |
Arthrogryposis | 1 (5.6%) | 0 (0.0%) | 0.1400 |
Hypertonia | 3 (16.7%) | 0 (0.0%) | 0.0020 |
Dysphagia/swallowing disorders | 2 (11.8%) | 0 (0.0%) | 0.0190 |
Seizures | 1 (5.6%) | 1 (0.9%) | 0.2610 |
NICU admission—no (%) | 3 (16.7%) | 14 (12.6%) | 0.6372 |
