Fig. 1: Molecular pattern distribution is represented by 4 clusters of pSS patients with different canonical pathways.
From: A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome
a Heatmap performed for 304 pSS patients (Discovery set: 227, Validation set: 77) showing the distribution of gene transcripts across the 4 clusters. In columns patients are grouped by cluster assignment and in rows genes are grouped by functional modules. Each subset of patients (discovery set on the left and validation set on the right) is presented separately. Red represents overexpression and blue represents under-expression. At the top of the figure annotations show: each of the treatment groups for each individual (AM: antimalarials, STED: steroids and IMS: immunosuppressors, red represents patients with treatment and gray represents patients without treatment), age (levels of yellow to green with yellow for younger patients and dark green for older patients), gender (red represents woman and gray represents man), ANTISSAPOS: anti-SSA/Ro antibody positivity, FOCUSSCOREPOS: focus score of ≥1 foci/mm2 (red represents focus score of ≥1 foci/mm2 and gray represents focus score of <1 foci/mm2). b Scatterplot of the first two components PCA (performed for 304 pSS patient and 330 HV) model showing clearly defined clusters in signature gene. HV (gray dot) are confused with C2 cluster (yellow dot). c Top 20 most significant canonical pathways for each cluster. Radar plots are represented according to ‒log (p-value) (Fisher’s exact test) associated to the most significant pathways of each cluster; C1 (pink), C3 (green), C4 (blue).
