Fig. 4: Cluster genome-wide association analyses (GWAS).
From: A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome
GWAS analysis was performed using Plink, an open-source whole genome association analysis toolset, using a logistical regression for 304 pSS (C1: 101, C2: 77, C3: 88 and C4: 38) patients and 330 healthy volunteers (HV) and each cluster was compared to HV. a Manhattan plots for each cluster are shown. b Linkage disequilibrium analysis in the loci of the 35 SNPs detected in C1 and located on chromosome 6 from base 29809362 to base 32681631. The R2 correlation coefficient and linkage disequilibrium heatmap were obtained with Plink, and oncofunco R package, respectively. Strongest associations between SNPs are annotated.
