Fig. 3: South African RBD mutant has a reduced response compared to UK RBD mutant. | Nature Communications

Fig. 3: South African RBD mutant has a reduced response compared to UK RBD mutant.

From: Immune response to SARS-CoV-2 variants of concern in vaccinated individuals

Fig. 3: South African RBD mutant has a reduced response compared to UK RBD mutant.The alternative text for this image may have been generated using AI.

UK (a) and South African (SA) RBD mutants (b) have differing effects upon antibody binding. RBD mutant antigens were generated and added to MULTICOV-AB to measure the immune response towards them in sera from vaccinated pre-second dose (light blue, n = 25), post second dose (dark blue, n = 20), and infected (red, n = 35) individuals, compared to the wild-type (wt) RBD. A linear curve (y = x) is shown as a dashed gray line to indicate an identical response between wild-type and mutant. Kendall’s tau was calculated to measure the ordinal association between the mutant and wild-type. Source data are provided as a Source Data file.

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