Fig. 8: A mechanism underlying METTL3-promoted ESCC development. | Nature Communications

Fig. 8: A mechanism underlying METTL3-promoted ESCC development.

From: METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding

Fig. 8

Overexpressed METTL3 increases the levels of the APC mRNA N6-methyladenosine, which recruits YTHDF to APC mRNA, to downregulate APC expression. Downregulated APC stabilizes β-catenin expression and promotes β-catenin-dependent gene expression for aerobic glycolysis, and ESCC cell proliferation and tumour growth.

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