Fig. 5: Genomically dependent T > C mutagenesis in Liver-HCC and other cancer types.
From: Learning mutational signatures and their multidimensional genomic properties with TensorSignatures
a C > A mutation type probabilities of HMF TS10-q and TS10-a for coding and template strand DNA. b Pooled HMF lung samples C > A variant counts from coding and template strand DNA in quiescent (Het and Quies, left) and epigenetically active regions (TssA, TssAFlnk, TxFlnk, Tx and TxWk, right). c T > C mutation type probabilities of PCAWG TS07 and TS08 for coding and template strand DNA. d Pooled PCAWG Liver-HCC T > C variant counts for coding and template strand DNA in epigenetically active and quiescent regions. e, f Transcriptional strand bias and A[T > C]/B[T > C] spectral shift in samples from different cancers with TS07 and TS08 contributions. Lines correspond to quadratic fits. Source data are provided as a Source Data file.
