Fig. 7: Model explaining the difference in the outcome of the egl-18(ga97) mutation between N2 and CB4856. | Nature Communications

Fig. 7: Model explaining the difference in the outcome of the egl-18(ga97) mutation between N2 and CB4856.

From: Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans

Fig. 7

Seam cell number distribution is shifted in egl-18 mutants in CB4856 (orange) compared with N2 (green) towards a higher average. Genetic variation in hsp-110 and other loci within the identified QTL regions in CB4856 may potentiate Wnt signalling and thus reinforce seam cell fate acquisition. This effect is only revealed in sensitised conditions, such as upon egl-18 loss-of-function or pop-1 RNAi.

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