Fig. 5: Overview of our approach to QTL fine-mapping. | Nature Communications

Fig. 5: Overview of our approach to QTL fine-mapping.

From: Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Fig. 5: Overview of our approach to QTL fine-mapping.

a Overview of merge analysis. LOD logarithm of the odds, QTL quantitative trait loci, DO diversity outbred, SNP single-nucleotide polymorphism, INDEL insertion–deletion, SV structural variant. b Overview of merge analysis as performed for the identification of missense variants. c Overview of merge analysis as performed for the identification of colocalizing trait QTL/gene eQTL within a locus. The pink columns around the QTL in each association plot represent the QTL 95% confidence intervals. The yellow box in c represents the gene search space for a locus, defined as the region within ±250 Kbp around the outer boundaries of the 95% confidence intervals within a locus. eQTL expression quantitative trait loci.

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