Fig. 6: QTL (locus 1) on chromosome 1. | Nature Communications

Fig. 6: QTL (locus 1) on chromosome 1.

From: Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

Fig. 6: QTL (locus 1) on chromosome 1.

a For each plot, the top panel shows allele effects for the DO founders for each of the eight QTL (quantitative trait loci) across an interval on chromosome 1 (Mbp, colors correspond to the founder allele in the legend). Bottom panels show each respective QTL scan. The red horizontal lines represent LOD (logarithm of the odds) score thresholds (genome-wide P < = 0.05). Colors indicate founder mouse strains: A/J (yellow), C57BL/6J (gray), 129S1/SvImJ (beige), NOD/ShiLtJ (dark blue), NZO/HILtJ (light blue), CAST/EiJ (green), PWK/PhJ (red), and WSB/EiJ (purple). b QTL scans across the same interval as a, after conditioning on rs50769082. c QTL scans after conditioning on rs248974780. Phenotype abbreviations: TMD tissue mineral density, ML medial–lateral femoral width, pMOI polar moment of intertia, Imax maximum moment of inertia, Ct.Ar/Tt.Ar bone area fraction, Tt.Ar total area, Ma.Ar medullary area, Ct.Por cortical porosity.

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