Fig. 7: Characterization of Qsox1.

a The top panel shows allele effects for the DO founders for Ier5 and Qsox1 expression an interval on chromosome 1 (Mbp, colors correspond to the founder allele in the legend). Y-axis units are best linear unbiased predictors (BLUPs). Bottom panels show each respective QTL scan. LOD (logarithm of the odds) score threshold for autosomal eQTL is 10.89 (alpha = 0.05). b Qsox1 expression in calvarial osteoblasts. For each time point, N = 3 independent biological replicates were examined. Error bars represent the standard error of the mean. TPM transcripts per million. c Single-cell RNA-seq expression data. Each point represents a cell (N = 7092 cells). The top panel shows UMAP clusters and their corresponding cell-type. The bottom panel shows the expression of Qsox1. The color scale indicates normalized gene expression value.